Fungal Disease Following Contaminated Steroid Injections

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چکیده

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Fungal meningitis due to contaminated epidural steroid injections.

In the fall of 2012, as we finalized this issue of , an unprecedented outbreak of fungal meningitis occurred that was caused by contaminated preservative-free methylprednisolone acetate solution from the New England Compounding Center used in epidural steroid injections in thousands of patients. The predominant pathogen was found to be Exserohilum rostratum (a black mold). Aspergillus fumigatus...

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Early clinical observations in prospectively followed patients with fungal meningitis related to contaminated epidural steroid injections.

UNLABELLED Chinese translation BACKGROUND Administration of epidural steroid injections (ESIs) with contaminated methylprednisolone resulted in an outbreak of fungal meningitis in many locations in the United States. OBJECTIVE To characterize early clinical findings and initial response to treatment. DESIGN Case series with standardized observation studied from 4 October to 31 October 201...

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Spinal and Paraspinal Fungal Infections Associated With Contaminated Methylprednisolone Injections

BACKGROUND A nationwide outbreak of fungal infections was traced to injection of Exserohilum-contaminated methylprednisolone. We describe our experience with patients who developed spinal or paraspinal infection after injection of contaminated methylprednisolone. METHODS Data were assembled from the Michigan Department of Community Health, electronic medical records, and magnetic resonance im...

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During 2012-2013, the US Centers for Disease Control and Prevention and partners responded to a multistate outbreak of fungal infections linked to methylprednisolone acetate (MPA) injections produced by a compounding pharmacy. We evaluated the effects of public health actions on the scope of this outbreak. A comparison of 60-day case-fatality rates and clinical characteristics of patients given...

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ژورنال

عنوان ژورنال: The American Journal of Pathology

سال: 2013

ISSN: 0002-9440

DOI: 10.1016/j.ajpath.2013.06.010